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    Some Work, All Play

    Some Work, All Play

    About

    Five to ten topics, sometimes about running, with lots of love and enthusiasm and science. We dig deep into training, races, studies, pop culture, and much more! With Megan Roche, M.D. and David Roche!

    Hosted By

    David Roche and Megan Roche

    310. The Fatigue Resistance Episode! Rachel Entrekin Makes History at Cocodona, Women v. Men Durability, Fueling and the Central Nervous System, Brain Changes, and More

    310. The Fatigue Resistance Episode! Rachel Entrekin Makes History at Cocodona, Women v. Men Durability, Fueling and the Central Nervous System, Brain Changes, and More

    May 12, 2026
    1h 34m

    We had some HYPOTHESES for this amazing episode! The main topics all revolved around fatigue resistance (often called “durability” in the literature), which we think is the most exciting area of training theory and physiology. It started with Rachel Entrekin’s legendary overall win at the Cocodona 250, an event that explores some of the strangest and coolest parts of endurance.

    Our big theory: what we’re seeing in these wild ultras is directly connected to what we see in short distances. A new study looked at fatigue resistance variations between men and women, with some shocking results. We expand the scope to talk about the literature generally before going to some ideas for how it all might relate to the central nervous system.

    ...And how it relates to fueling. You could probably guess that we were going to talk about carbs.

    Plus, we answer questions about the culture of fueling for young athletes and feeling good after long runs!

    This one starts with a description of Megan’s health journey. The hottest vacation is apparently a 3-day stay in Boulder Community Hospital. Things are scary, but we’re holding onto hope for the future.

    We love you all! HUZZAH!

    -David and Megan

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    More from Some Work, All Play

    311. The Science Episode! How To Stop Cramps, Fat Oxidation Changes, Missing Link Heat Training, The Difficulty of Physiology Data, and More

    311. The Science Episode! How To Stop Cramps, Fat Oxidation Changes, Missing Link Heat Training, The Difficulty of Physiology Data, and More
    May 19, 2026

    309. The Marathon that Changed Running, Ultra GOAT to Western States, Misconceptions about Training Volume, A Supershoe Lawsuit, and A Hydration Study!

    309. The Marathon that Changed Running, Ultra GOAT to Western States, Misconceptions about Training Volume, A Supershoe Lawsuit, and A Hydration Study!
    May 5, 2026

    308. Sub-2 Hour Marathon Fueling, The High Carb Plus Bicarb Era, Strides v. Plyometrics Study, Supershoe Evolution, and Iron Theories!

    308. Sub-2 Hour Marathon Fueling, The High Carb Plus Bicarb Era, Strides v. Plyometrics Study, Supershoe Evolution, and Iron Theories!
    April 28, 2026