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    Some Work, All Play

    Some Work, All Play

    About

    Five to ten topics, sometimes about running, with lots of love and enthusiasm and science. We dig deep into training, races, studies, pop culture, and much more! With Megan Roche, M.D. and David Roche!

    Hosted By

    David Roche and Megan Roche

    328. Mysteries of Fatigue Resistance, New Science on the Lactate Shuttle, Carbs and Bone Health, and Fatigue Miles

    328. Mysteries of Fatigue Resistance, New Science on the Lactate Shuttle, Carbs and Bone Health, and Fatigue Miles

    September 15, 2026
    1h 26m

    We had regrettable hot takes on cleaning exercise equipment before this great episode! The main training topic was on a new study highlighting the important of the lactate shuttle. We zoom out to discuss the implications for aerobic training. 

    We also talked about mysteries around fatigue resistance! In the lab, you can’t predict fatigue resistance from fresh values (or from metabolic values during training). What are the implications? Our framework of “carb ox after fat ox” can provide some options.

    Other topics: Megan’s return to racing, a formal apology, a new study on hand and arm cooling, exercise science gone wrong in the NFL, bone health and carbs, and questions on the 6-12-18-24 challenge, wedding speeches, fatigue miles in the context of zone compression theory, and improving bike power for runners.

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